Stewardship is potentially a usefulconcept in modernizing management philosophies. Use ofthe term has increased markedly in recent years, yetthe term is used loosely and rarely defined in landmanagement literature. The connections between thispractical usage and the ethical basis of stewardshipare currently poorly developed. The followingdefinition is proposed: ``Stewardship is theresponsible use (including conservation) of naturalresources in a way that takes full and balancedaccount of the interests of society, futuregenerations, and other species, as well as of privateneeds, and accepts significant answerability (...) tosociety.'''' A religious interpretation would require thephrase ``and ultimately to God'''' to be added.Stewardship has both secular and religiousinterpretations and it will be desirable to developboth of these aspects in parallel. A task forphilosophers is to establish whether the ethical basisof stewardship is sufficient to address environmentalconcerns or whether it is necessary to embrace widerethical approaches. Stewardship occupies similarground to several other concepts of use and managementof resources, particularly sustainability. It canbuild on sustainability by encouraging a broader viewof who and what should benefit from managementactivity. In particular, it focuses attention on therole of managers in providing public benefit and onenvisaging other species as a form of ``stakeholder'''' inmanagement decisions. Stewardship is applicable acrossthe widest range of fields of resource use and alsohas relevance to aspects of land tenure and propertyrights. Application of stewardship will require someadjustments in the roles of private managers/ownersvis-à-vis government. It might providemanagers with an expanded role and, importantly, amore positive image, both of themselves and in theeyes of the public. Stewardship could alsobe developed in a way that has relevance to citizensin general (as opposed to managers and owners ofresources), through their interactions with naturalresources as consumers. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

The elevation of ordinary, functional, and task‐based movements were cast as a central aesthetic strategy in the dance concerts at the Judson Memorial Church. A dance ontology focused on an art product could emerge from dance's choreographic structure. A twist to Danto's indiscernibility demands that the performative aspect of the dance medium requires more to capture the aliveness that stilled objects of art do not have.Yvonne Rainer's innovation gives credence to the aliveness in an art capable of always reinventing the (...) ordinary. Aliveness becomes the aboutness of dance. Danto's embodiment amounts to “symbolic expression.” One way Rainer achieved an embodied everydayness was by including artists with no dance training such as Rauschenberg or Morris, or the composer Philip Corner. Dance historian Sally Banes has shown the way Rainer's development of the everyday could be seen as part of a larger investigation. (shrink)

A method now popular for fixing the scopes of arguments involves a covert movement operation, named QR (for Quantifier Rule) by Robert May. May envisioned QR as a kind of adjunction operation, attaching the arguments so affected to phrases dominating that argument. From the surface representation in (1a), for instance, QR can fashion the representations in (1b) and (1c) by adjoining the object and/or subject argument to IP. (1) a. [IP Someone [VP loves everyone ]]. b. [IP everyone1 [IP someone (...) [VP loves t1 ]]]. c. [IP someone2 [IP everyone1 [IP t2 [VP loves t1 ]]]] As the representations in (1a,b) suggest, QR has syntactic consequences rather like those displayed by Topicalization, the process that derives (2b) from (2a). (shrink)

One of the interests in the Gapping construction is the headache it causes for those trying to get constituency structure right. On the assumption that Gapping, like other processes of sentence grammar, respects constituency, it is very hard to deliver the right constituents in cases such as (1). (1) a. Some consider him honest and others consider him pleasant. b. The faculty brought scotch to the party and the students brought beer to the party. c. The girls occasionally ate peanuts (...) and the boys occasionally ate breath mints. (Understand the material in strikeouts to be Gapped.) Everything else tells us that the Gapped strings in (1) should not form a constituent which excludes the material left behind. Yet, the fact that only when the verb Gaps may the other material too suggests just the opposite. That is, if we deny that the verb forms a constituent with the other material, and let Gapping apply to each of the elided constituents independently, we would have no way to express this dependency. If we let Gapping only elide constituents that house the verb, on the other hand, it follows. (shrink)

We comment on the proposition “that lower temperatures and especially greater seasonal variation in temperature call for individuals and societies to adopt … a greater degree of self-control” (Van Lange et al., sect. 3, para. 4) for which we cannot find empirical support in a large data set with data-driven analyses. After providing greater nuance in our theoretical review, we suggest that Van Lange et al. revisit their model with an eye toward the social determinants of self-control.

This paper looks at an approach to Principle C in which the disjoint reference effect triggered by definite description arises because there is a preference for using bound pronouns in those cases. Philippe Schlenker has linked this approach to the idea that the NP part of a definite description should be the most minimal in content relative to a certain communicative goal. On a popular view about what the syntax and semantics of a personal pronoun is, that should have the (...) effect of favoring a pronoun over a definite description. This paper shows how that can be made the source of “Vehicle Change,” an effect in ellipsis contexts in which definite descriptions seem to behave like pronouns. It requires, however, a way of distinguishing bound pronouns from non-bound pronouns, and the paper makes a proposal about how these two kinds of pronouns can be distinguished in the way needed. (shrink)

I defend a thesis called metaethical intentionalism, according to which deontic moral judgments (“ought” judgments) are intersubjective intentions or verbal expressions of intersubjective intentions. They have the form, “We shall any of us do A in C,” or are derivable from such practical commitments. They are universalizable by virtue of their content (“… any of us …”) and sharable by virtue of their form (“We …”). My account of the moral “ought” is inspired by the moral writings of Wilfrid Sellars (...) (1912–1989). While I draw on his work and offer interpretations, my primary aim is to develop and refine Sellars’s metaethical legacy, extending and applying it to metaethical issues he did not fully address. In Chapter I, I articulate and argue for the theory’s main claims. I also construct a novel interpretation of Sellarsian we-intentions, one that resists a collectivist reading of the first-person-plural “we” that animates the moral point of view. In Chapter II, I create a taxonomy of practical disagreements and use the theory’s resources to identify the loci of moral disagreements at various nodes in web-like patterns of practical inference. In Chapter III, I address internalism–externalism debates about moral motivation and reasons for action. I argue that metaethical intentionalism commits us to both internalisms, and I show that it provides powerful resources for meeting motivational externalists’ objections and explaining away the appeal of externalism about reasons. (shrink)

Ce texte offre un aperçu des articles composant ce numéro spécial et présente brièvement les principaux arguments avancés dansA Conceptual Investigation of Justice, dont une des thèses centrales veut qu’un important désaccord à la fois sémantique et philosophique sur la définition du terme «justice» soit au cœur de plusieurs questions en philosophie politique contemporaine. Cette présentation nous amène par ailleurs à décrire les caractéristiques d’un débat sémantique dont la portée dépasse la stricte sphère linguistique.

In C. S. Lewis’s Christian Apologetics: Pro and Con, I took the con in a debate with Victor Reppert about the soundness of Lewis’s famous “argument from reason.” Reppert then extended his argument in an article for Philosophia Christi; this article is my reply. I show that Reppert’s argument fails for three reasons. (1) It “loads the die” by falsely assuming that naturalism, by definition, can't include mental causation "on the basic level." (I provide multiple examples of naturalist theories of (...) mind that do exactly that). (2) Physical processes can reliably produce true beliefs. And (3) reasoning isn’t necessarily mental. (shrink)

Ethics isn’t a conversation exclusive to philosophers. There is value, then, in not only understanding how laypeople think about issues in ethics, but also bringing their judgments into dialogue with those of philosophers in order to make sense of agreement, disagreement, and the consequences of each. Experimental philosophers facilitate this dialogue uniquely by capturing laypeople’s judgments and analyzing them in light of philosophical theory. They have done so almost exclusively by using face valid quantitative surveys about philosophically interesting thought experiments. (...) Based on high participant support for this or that response, researchers conclude that a given theory is more or less intuitive, and in some cases that it is or isn’t true. However, such conclusions can only be drawn from quantitative survey data if one assumes those data accurately reflect laypeople’s thinking on the issues of interest, an assumption that can’t be justified by the quantitative data itself since they are potentially opaque. This is the methodological problem of experimental philosophy: experimental philosophers who use quantitative methods alone can’t sufficiently demonstrate their data to be reflective of relevant judgments/intuitions. To better explore people’s judgments on issues in ethics and to determine whether experimental philosophers are or aren’t getting what they take themselves to be getting in surveys, I recreated part of an experiment by Chituc, Henne, Sinnott-Armstrong, and De Brigard on the Kantian principle that “ought implies can”, or that whenever an agent ought to do something then it is the case that she can, and added a layer of qualitative data to it by having participants think aloud while completing the surveys and conduct a follow-up interview. With similar quantitative results to those from Chituc et al., I argue that my qualitative results 1) cast doubt on Chituc et al.’s data being reflective of many people’s judgments, especially on the more interesting questions relating to moral obligation; 2) reveal unique insights into how people think about OIC; 3) generally speak to the value of experimental philosophers using triangulation of methods in better understanding laypeople’s complex and varied thinking about questions important to ethics and beyond. Supplemental documents: Appendices A, B, C, D, and E are surveys I used in my study. Appendices C and D are derived from Chituc et al.’s publication “Blame, Not Ability, Impacts Moral ‘Ought’ Judgments for Impossible Actions: Toward an Empirical Refutation of ‘Ought’ Implies ‘Can.’” Appendix F is the recruitment flyer I distributed for my study. Appendix H is the quantitative data from my study. (shrink)

BackgroundThe increased risk of developing attention-deficit hyperactivity disorder (ADHD) in extremely preterm infants is well-documented. Better understanding of perinatal risk factors, particularly those that are modifiable, can inform prevention efforts.MethodsWe examined data from the Extremely Low Gestational Age Newborns (ELGAN) Study. Participants were screened for ADHD at age 10 with the Child Symptom Inventory-4 (N = 734) and assessed at age 15 with a structured diagnostic interview (MINI-KID) to evaluate for the diagnosis of ADHD (N = 575). We studied associations (...) of pre-pregnancy maternal body mass index (BMI), pregestational and/or gestational diabetes, maternal smoking during pregnancy (MSDP), and hypertensive disorders of pregnancy (HDP) with 10-year and 15-year ADHD outcomes. Relative risks were calculated using Poisson regression models with robust error variance, adjusted for maternal age, maternal educational status, use of food stamps, public insurance status, marital status at birth, and family history of ADHD. We defined ADHD as a positive screen on the CSI-4 at age 10 and/or meeting DSM-5 criteria at age 15 on the MINI-KID. We evaluated the robustness of the associations to broadening or restricting the definition of ADHD. We limited the analysis to individuals with IQ ≥ 70 to decrease confounding by cognitive functioning. We evaluated interactions between maternal BMI and diabetes status. We assessed for mediation of risk increase by alterations in inflammatory or neurotrophic protein levels in the first week of life.ResultsElevated maternal BMI and maternal diabetes were each associated with a 55–65% increase in risk of ADHD, with evidence of both additive and multiplicative interactions between the two exposures. MSDP and HDP were not associated with the risk of ADHD outcomes. There was some evidence for association of ADHD outcomes with high levels of inflammatory proteins or moderate levels of neurotrophic proteins, but there was no evidence that these mediated the risk associated with maternal BMI or diabetes.ConclusionContrary to previous population-based studies, MSDP and HDP did not predict ADHD outcomes in this extremely preterm cohort, but elevated maternal pre-pregnancy BMI, maternal diabetes, and perinatal inflammatory markers were associated with increased risk of ADHD at age 10 and/or 15, with positive interaction between pre-pregnancy BMI and maternal diabetes. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

The central classical liberal insight is that private property appears both to protect personal liberty and to promote general productivity. By way of philosophically clarifying this insight, Escape from Leviathan (EfL) posits the extreme classical liberal, or libertarian, Compatibility Thesis: there is no long-term, systemic, practical conflict among economic rationality, interpersonal liberty, human welfare, and private-property anarchy (i.e., four plausible and relevant theories of these that are presupposed, or entailed, by libertarianism and consonant social science). The review (Liberty, November 2002) (...) holds that this extreme version is probably false and suggests that perhaps even EfL’s author would agree. He (still) does not, although he remains open to argument. But what anyone happens to believe at any particular moment is a piece of fleeting biography that is irrelevant to the truth of the thesis or the soundness of the arguments in EfL. (shrink)

Contra critical rationalism, the response begins by referring to “the variety of internalist and externalist versions of foundationalism” (Liberty, December 2002). But it makes no attempt to explain or defend any of them. Hence, no further criticism is due here. The response then argues that, “The critical rationalist method seems to suggest that Lester’s extreme compatibility thesis is probably false” because—quoting Escape from Leviathan (EfL)—“bold universal theories might be false, and probably are” and yet “he doesn’t think the thesis is (...) probably false”. And so this is, by implication, an inconsistent belief. But the Compatibility Thesis (CT) is not one of the “bold universal theories” of science. The review and the response appear, at times, to assume that the CT is a bold universal theory about the perfect compatibility of applying the relevant conceptions, or theories, of rationality, liberty, welfare, and anarchy. Then, at other times, they assert that it is not bold at all but merely about definitions designed to be compatible. In fact, the CT asserts both that there are no theoretical incompatibilities among relevant and plausible versions of the theories, and that there are no actual long-term, systemic, and practical conflicts among applying them. That is still a bold theory (perhaps even most libertarians would disagree with it), but it’s not a universal thesis of perfect compatibility. And if it were good practice to reject a theory just because of its boldness, then all scientific theories would be immediately rejected without even trying to produce a falsification. In any case, as stated in the reply to the review, anyone’s mere beliefs are irrelevant to the truth of objective theories and the soundness of objective arguments. (shrink)

Although Sibawayh dealt with it in a scattered manner under different headings there have been different views on na't (adjective), which is gene-rally included in the tawabi group in Arabic syntax, and there have been debates around these views. Na't, which is categorized as a proper adjective and qualifies the meaning of man'ut (mawsuf), has different characteristics from the sentence elements that indicate the subject. Nahiv scholars have mostly divided na't into two parts: real and causal na't, and they have (...) formulated certain rules for these two parts in accordance with the structure of the Arabic language. Since na't and man'ut are accepted as nouns, the i'rab of na't is subject to men'ut. However, some examples in the Qur'an and some expressions used by the Arabs caused objections to the i'rab of na't being the same as men'ut. It is observed that these objected examples are the cases where men'ut is known and the exceptional cases of madih, zam and jarri jivar. It is also obligatory for the na't to conform to the man'ut in terms of ma'rifiyyah, nekiriyyah, custom and gender. While Sibawayh (d. 180/796) considered it qabh (ugly) for non-propositional words to be na't, scholars such as Ibn Hisham (d. 218/833), Ibn al-Ḥajib (d. 646/1249), and Abd ar-Rahman Jami (d. 898/1492) accepted that na't could be either propositional or non-propositional and cited many examples of na't in the case of non-propositional words. Scholars such as Ibn Jinni (d. 392/1002) and Ibn al-Hajib gave an explanation of the causative na't without naming it, scholars such as Ebu’l-Bekā al-Ukbari (d. 616/1219) analyzed the subject under the title of causative adjective or causative na't, and Halid b. Abdullah al-Azhari discussed it under the title of al-wasf al-majazi. The subject of our study is to examine the handling of na't, which is one of the sentence elements in the Arabic language, in the works written on the field, its parts, the dimension that affects the meaning and the controversial aspects. The aim of the research is to examine the rules that Sibawayh deals with in his al-Kitâb on na'ta and the objections of later Arab linguists to these rules, and to contribute to the field by revealing different views on the subject. (shrink)

J. F. C. Harrison has written that ‘for each age there is a new view of Mr Owen’, which is proof of the fertility and continuing relevance of his ideas. Not just in Britain and America but today around the world anti-poverty campaigners, birth-controllers, collectivists, communitarians, co-operators, ecologists, educationalists, environmentalists, feminists, humanitarians, internationalists, paternalistic capitalists, secularists, campaigners for social justice, trade unionists, urban planners, utopians, welfare reformers can all find something to admire and inspire in the treasure trove that is (...) the thought and actions of Robert Owen. Owen was a creative genius of global significance, a radical writer and activist of international reputation and reach who has inspired those seeking to change human society for the better. The contributors to this volume include not only many of the recognized experts on the life, work and legacy of Owen, but also work from younger scholars or scholars coming to the field afresh. The volume presents the most recent and original research on Owen. Owen notoriously (and impressively) dabbled in many spheres, and this is reflected in the its breadth of content. The unifying themes are Owen’s profile in his own time, and the relevance of his ideas for the generations that followed. His importance for educational and social philosophy, for political economy and for the political theory of socialism are all discussed, as are his contribution as a philanthropic employer, his political activities and the specificities of his historical context. (shrink)

Western societies today are coming unmoored in the face of an earth-shaking ethical and cultural paradigm shift. At its core is the question of what it means to be human and how we are meant to live. The old answers are no longer accepted; a dizzying array of options are offered in their stead. Underpinning this smorgasbord of lifestyles is a thicket of unquestioned assumptions, such as the separation of gender from biological sex, which not so long ago would have (...) been universally rejected as radical notions. In the spring of 2019, a group of Orthodox Christian scholars drawn from a wide variety of academic disciplines met together to offer responses to the moral crisis our generation faces, elaborating upon its various forms and facilitating a fuller understanding of some of its theological and philosophical foundations. In doing so they offer support to all those who question the claims that are so forcefully insisted upon today--a clarity that will aid them in standing up and resisting trends that have already shown to be the cause of great suffering and unhappiness. (shrink)

‘Mysticism means to isolate the eternal from the originated.’ This is not my definition of the word ‘mysticism’ but that of the founder of the ‘orthodox’ school of Muslim mysticism, Al-Junayd of Baghdad who flourished in the ninth century a.d . In actual fact it is not a definition of mysticism at all but of the Arabic word tawḥīd which means primarily ‘the affirmation of unity’; and that surely is an essential ingredient of any form of mysticism: it is the (...) affirmation through personal experience of unity either absolutely or in some qualified sense. (shrink)

As everyone knows, since the end of the Second World War there has been a sensational revival of interest in the non-Christian religions particularly in the United States and in this country. The revival has taken two forms, the one popular, the other academic. The first of these has turned almost exclusively to Hindu and Buddhist mysticism and can be seen as an energetic reaction against the dogmatic and until very recently rigid structure of institutionalised Christianity and a search for (...) a lived experience of the freedom of the spirit which is held to be the true content of mysticism, obscured in Christianity by the basic dogma of a transcendent God, the ‘wholly Other’ of Rudolf Otto and his numerous followers, but wholly untrammelled by any such concept in the higher reaches of Vedanta and Buddhism, particularly in its Zen manifestation. On the academic side the picture is less clear. There is, of course, the claim that the study of religion, like any other academic study, must be subjected to and controlled by the same principles of ‘scientific’ objectivity to which the other ‘arts’ subjects have been subjected, to their own undoing. But even here there would seem to be a bias in favour of the religions of India and the Far East as against Islam, largely, one supposes, in response to popular demand. (shrink)

Early in World War I, Virginia Woolf wrote these words: ‘The future is dark, which is on the whole, the best thing the future can be […]’. It is tempting to assume that darkness simply hides the unknown and the threatening. It is more challenging to think of it as Woolf did: rich with possibility in even the most desperate times.We live in what many would readily describe as dark times. These times have brought (among much else) a once-in-a-century public (...) health crisis, the continued redemption of toxic white supremacy, declining trust in and support for public institutions, and growing evidence of impending climate devastation. ‘Dark Futures’ will consider some of the scenes of this devastation and mine them for insights into our predicaments and our prospects. (shrink)